In mammals, genomic imprinting results in the monoallelic expression of a subset of genes in a parent-of-origin specific manner. This complex process is regulated by the Imprinting Control Regions (ICRs) and germline Differentially Methylated Regions (gDMRs). In the mouse and the human genomes, the known ICRs/gDMRs include a set of composite DNA elements consisting of the ZFP57 binding site (ZFBS) overlapping a subset of the MLL1 morphemes. It is thought that these composite elements (ZFBS-Morph overlaps) could be a key feature that drives the recruitment of the DNMT3A and DNMT3L complex for processive methylation of the ICRs in one of the parental alleles. Furthermore, while ZFP57 selectively binds a CpG-methylated hexameric DNA sequence, MLL1 and MLL2 associate with a set of nonmethylation CpG-rich motifs known as the MLL1 morphemes. Both MLL1 and MLL2 regulate transcription by modifying lysine 4 in histone H3 producing H3K4me3 marks in chromatin.
This publication provides a text file that lists the positions of ZFBS and ZFBS-Morph overlaps in the build bosTau8 of the cow genome. The file is in a format (.bed) suitable for upload at the UCSC genome browser to create a custom track. To obtain and save a copy of the bed file, click on download at the top right corner of the page. Alternatively, click here to examine directly the listed positions at the UCSC genome browser.
If you observe anomalies on this page and if you encounter a problem with downloading the bed file, please contact bina@ purdue.edu.
Cite this work
Researchers should cite this work as follows:
- Bina, M., Wyss, P., Song, X. (2019). The positions of ZFBS and ZFBS-Morph overlaps in the build bosTau8 of the cow genome. Purdue University Research Repository. doi:10.4231/K1SE-T951