The positions of ZFBS and ZFBS-Morph overlaps in the build hg19 of the human genome

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By Minou Bina1, Phillip J. Wyss1, Xiaohui Carol Song1

Purdue University

Supplementary material for the publication entitled “Discovering candidate imprinted genes and Imprinting Control Regions in the human genome” Bina M. bioRxiv (2019), doi: 10.1101/678151.

Version 1.0 - published on 30 May 2019 doi:10.4231/SK8Y-EA21 - cite this Archived on 30 Jun 2019

Licensed under CC0 1.0 Universal

Description

Proteins that bind CpG containing sequences play central roles in numerous biological processes including the regulation of transcription and genomic imprinting.  Among these proteins, MLL1 and MLL2 bind a set of nonmethylation CpG-rich motifs, known as the MLL1 morphemes, in order to regulate transcription.  In contrast, ZFP57 binds a methylated hexameric DNA sequence.  ZFP57 functions in genomic imprinting.  In mammals, genomic imprinting results in the monoallelic expression of a subset of genes in parent-of-origin specific manner.  This complex process is regulated by the Imprinting Control Regions (ICRs) and germline Differentially Methylated Regions (gDMRs).  In the mouse genome, the known gDMRs include a set of composite DNA elements consisting of the ZFP57 binding site (ZFBS) overlapping a subset of the MLL1 morphemes.  It is thought that these composite elements (ZFBS-Morph overlaps) could be a key feature that drives the recruitment of the of DNMT3A andDNMT3L for processive methylation of the ICRs in one of the parental alleles.

This publication provides a text file that lists the positions of ZFBS and ZFBS-Morph overlaps in the build hg19 of the human genome.  The file is in a format (.bed) suitable for upload at the UCSC genome browser to create a custom track.  At the top right corner of the page, click on download to obtain and save a copy of the bed file.  Alternatively, click here to examine the listed positions directly at the UCSC genome browser.  If you observe anomalies on this page and if you encounter a problem with downloading the bed file, please contact bina@ purdue.edu

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