Proteins that bind CpG containing sequences play central roles in numerous biological processes including the regulation of transcription and genomic imprinting. Among these proteins, MLL1 and MLL2 bind a set of nonmethylation CpG-rich motifs, known as the MLL1 morphemes, in order to regulate transcription. In contrast, ZFP57 binds a methylated hexameric DNA sequence. ZFP57 functions in genomic imprinting. In mammals, genomic imprinting results in the monoallelic expression of a subset of genes in parent-of-origin specific manner. This complex process is regulated by the Imprinting Control Regions (ICRs) and germline Differentially Methylated Regions (gDMRs). In the mouse genome, the known gDMRs include a set of composite DNA elements consisting of the ZFP57 binding site (ZFBS) overlapping a subset of the MLL1 morphemes. It is thought that these composite elements (ZFBS-Morph overlaps) could be a key feature that drives the recruitment of the of DNMT3A andDNMT3L for processive methylation of the ICRs in one of the parental alleles.
This publication provides a text file that lists the positions of ZFBS and ZFBS-Morph overlaps in the build hg19 of the human genome. The file is in a format (.bed) suitable for upload at the UCSC genome browser to create a custom track. At the top right corner of the page, click on download to obtain and save a copy of the bed file. Alternatively, click here to examine the listed positions directly at the UCSC genome browser. If you observe anomalies on this page and if you encounter a problem with downloading the bed file, please contact bina@ purdue.edu
Cite this work
Researchers should cite this work as follows:
- Bina, M., Wyss, P. J., Song, X. C. (2019). The positions of ZFBS and ZFBS-Morph overlaps in the build hg19 of the human genome. Purdue University Research Repository. doi:10.4231/SK8Y-EA21