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Potential Transcription Factor Binding Sites in the Human Genome (hg19)

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By Minou Bina, Phillip J. Wyss1

Purdue University, Department of Chemistry

Supplementary material for the article entitled “Discovering sequences with potential regulatory characteristics”. Bina M., Wyss P., et al. Genomics 93:314-22 (2009).

Version 1.0 - published on 08 Oct 2014 doi:10.4231/R7JM27JN - cite this Archived on 25 Oct 2016

Licensed under CC0 1.0 Universal

Description

Access dataset in genome browser. Transcription factors bind specific DNA sequence elements to control the expression of genes.  In the human genome, Transcription factor Binding Sites (TFBSs) are dispersed in regulatory segments localized upstream, within, or downstream of genes.  In this publication, we offer the position of potential TFBSs for protein-coding genes. The binding sites were collected from articles reporting results of DNA binding assays, functional assays, or both.  As an earlier version (Crowley, Roeder, and Bina, J. Mol. Biol. 268:8-14, 1997), the current collection (p51) does not include sites that occur frequently in human genomic DNA.  This publication offers a link for viewing the position of TFBSs directly on the genome browser (hg19) and provides the corresponding file for download. The file is in .bb (bigBed) format. To obtain a copy (BINA_TFBS_p51_hg19_.bb), click on download (displayed at the top right of this page).  You can use the downloaded file to create a custom track on the human genome browser (hg19).  To display TFBSs on a track, include the instructions shown below: db=hg19 position=chr1:1-249250621 track type= bigBed name=“ TFBSs” description=“BINA TFBSs version p51” visibility=pack Alternatively, click on TFBSs in hg19 to view the position of TFBSs directly on a track at the human genome browser at UCSC.  While using the browser, select Dense to view the positions in long genomic DNA sequences. Select Pack when zooming to short DNA segments. If you use the data in your research, please cite the primary publication by Bina et al. Genomics 93:314-22 (2009).

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