Localization of MLL1 morphemes in mouse mm9 genomic DNA

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By Minou Bina1, Phillip J. Wyss1, Daidong Wang1, Xiaohui C. Song2

1. Purdue University, Department of Chemistry 2. Purdue University, Academic Technologies and Rosen Center for Advanced Computing

Supplementary materials for the publication entitled “Discovery of MLL1 binding units, their localization to CpG Islands, and their potential function in mitotic chromatin.” Bina M, Wyss P, et al. BMC Genomics. 14:927 (2013)

Version 1.0 - published on 01 Apr 2014 doi:10.4231/R7KW5CXF - cite this Archived on 25 Oct 2016

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Access in genome browser. Mixed Lineage Leukemia 1 (MLL or MLL1) plays central roles in the regulation of protein-coding genes. Previous studies of mice have established that MLL1 controls key developmental pathways including the formation of body plan during the early stages of embryogenesis. Even though MLL1 is best known for catalyzing methylation of lysine 4 in histone H3 (H3K4), reported data indicate that MLL1 performs histone methyltransferase-independent functions including gene-bookmarking during mitosis, favoring genes that were highly transcribed during interphase, to accelerate reactivation of transcription following mitotic exit (Blobel ''et al''., ''Mol Cell''. 2009). By analyzing results of reported DNA binding and chromatin immunoprecipitation assays, we have uncovered the DNA sequence elements that bind the MT-domain in MLL1: Bina et. al, BMC Genomics 14:927 (2013). We describe these elements as minimal units or morphemes: the smallest ‘words’ in DNA that selectively bind the MLL1 MT-domain. This publication provides a file (BINA_MLL_morphemes_mm9.bed) to display the position of MLL1 morphemes in the genome browser at UCSC. You can obtain a copy of the bed file (in text format) by clicking on download. Alternatively, you can use the link below to view the position of MLL1 morphemes directly on a track in the browser at UCSC. While using the genome browser, select Dense to view morpheme positions in genomic DNA. Select pack when zooming to short DNA segments. Open the position of MLL1 morphemes in the mouse built mm9 genomic DNA. If you use the data in your research, please cite the primary publication by Bina et al., published in BMC Genomics 14:927 (2013).

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