Climate change is forcing changes in agricultural production methods and research. Increasing temperatures are one of the prominent problems associated with climate change. Heat stress in maize can influence the overall health and production of the crop with yield losses realized through premature senescence or death of vegetative and reproductive structures. The scientific community is just beginning to examine the effects of high temperatures on maize growth and development. The Heat Tolerant Maize for Asia (HTMA) project is a Global Development Alliance to increase our understanding of heat stress tolerance in maize with partners including CIMMYT, Purdue University, and Pioneer Hi-Bred as well as National Agricultural Research Systems (NARS) and seed companies from South Asia through the support of USAID. These partners have teamed up for research to understand heat stress tolerance of maize at the physiological and genetic level and to create superior hybrids that thrive under these conditions. Research studies are being conducted to find metabolic signals and DNA markers for heat stress tolerance. Plant breeding efforts will utilize doubled haploids and genomic selection to identify and develop improved maize hybrids for high-temperature environments.